Laman A. Al-Razzak, Panayiotis P. Costantinides, Dilip Kaul, John Lipari, Lisa McChesney-Harris and Bashar Y. Abdullah, US6,008,192, 12/28/99, Hydrophilic Binary Systems for the Administration of Lipophilic Compounds.
Karel Lambert, Panayiotis P. Constantinides, Alex Tustian and Steven C. Quay, US6,458,373, 10/1/02; US 6,660,286, 12/9/03, Emulsion Vehicle for Poorly Soluble Drugs.
Panayiotis P. Constantinides, Karel Lambert, Alexander Tustian and Andrew Nienstedt, US6,479,540, 11/12/02, Compositions of Tocol-Soluble Therapeutics.
Robert E. Dudley and Panayiotis P. Constantinides, EP1871384, 1/2/08, Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Comprising Same.
Panayiotis P. Constantinides, Likan Liang and Eun-Hyan Jang, EP1460992, 3/11/09, US 8,535,650, 9/17/13, Stabilized Reverse Micelle Compositions and Uses Thereof.
Arthur Michaelis and Panayiotis P. Constantinides, EP 2056835, 5/13/09, Pharmaceutical Compositions and Uses Thereof.
Robert E. Dudley and Panayiotis P. Constantinides, US 8,241,664, 8/14/12, Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Comprising Same.
Robert E. Dudley and Panayiotis P. Constantinides, US 8,492,369, 7/23/13, Oral Testosterone Ester Formulations and Methods of Treating Testosterone Deficiency Comprising Same.
Jerald W. Darlington and Panayiotis P. Constantinides, US 8,481,084, 7/9/13, Cholesterol-Interacting Layered Phyllosilicates and Methods of Reducing Hypercholesteremia in a Mammal.
Robert E. Dudley and Panayiotis P. Constantinides, US 8,492,369, July 23, 2013, Oral Testosterone Ester Formulations and Methods of Treating Testosterone Deficiency Comprising Same.
Panayiotis P. Constantinides, Likan Liang and Eun-Hyun Jang, US 8,535,650, September 17, 2013, Stabilized Reverse Micelle Compositions and Uses Thereof.
Robert E. Dudley and Panayiotis P. Constantinides, US 8,778,916, July 15, 2014, Oral Testosterone Ester Formulations and Methods of Treating Testosterone Deficiency Comprising Same.
Robert E. Dudley and Panayiotis P. Constantinides, US 8,778,917, July 15, 2014, Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Comprising Same.
Robert E. Dudley and Panayiotis P. Constantinides, US 8,828,428, September 9, 2014, Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Comprising Same.
Wael Salameh and Panayiotis P. Constantinides, US 10,245,273 April 2, 2019, Use of Oral Pharmaceutical Products Combining Testosterone Esters with Hypolipidemic Agents.
Panayiotis P. Constantinides, Jean-Paul Scalart, Cindy Lancaster, Joseph Marcello, Gary Marks, Harma Ellens and Philip Smith (1994), Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Containing Medium-Chain Glycerides, Pharm. Res. 11:1385-1390.
Panayiotis P. Constantinides, Karel Lambert, Alexander K. Tustian, Wenwen Ma, Brian Schneider, Salima Lalji, Bryan Wentzel, Dean Kessler, Dilip Worah and Steven C. Quay (2000), Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel, Pharm. Res. 17:175-182.
Pavel Gershkovich, Jerald Darlington, Panayiotis P. Constantinides and Kishor M. Wasan (2009), Inhibition of Intestinal Absorption of Cholesterol by Surface-Modified Nanostructured Aluminosilicate (NSAS) Compounds, J. Pharm. Sci. 98: 2390-400.
George Mattheolabakis. Ting Nie, Panayiotis P. Constantinides and Basil Rigas (2012), Sterically Stabilized Liposomes Incorporating the Novel Anticancr Agent Phospho-Ibuprofen (MDC-917) : Preparation, Characterization and In Vitro/In Vivo Evaluation, Pharm. Res. 29 : 1435-1443.
Xie, G., Wong, C.C., Cheng, K.W., Huang, L., Constantinides, P.P. and Rigas, B. (2012) In Vitro and In Vivo Studies of Phospho-Aspirin (MDC-22). Pharm. Res. 29 : 3292-3301.
R. Zhu, K.W.Cheng, G. Makenzie, L. Huang, Y. Sun, G.Xie, K.Vrankova, P.P.Constantinides and B. Rigas (2012) Phospho-Sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice : Enhanced Efficacy and Mitochondria Targeting by its Formulation in Solid Lipid Nanoparticles, Pharm Res. 29 : 3090-3101.
George Mattheolabakis, Chi C. Wang, Yu Sun, Carol Ann Amelia, Robert Richards, Panayiotis P. Constantinides and Basil Rigas (2014) Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolysable by esterases : A study of phospho-ibuprofen, J. Pharmacol. Exp. Ther. 351: 61-66.
Panayiotis P. Constantinides (1995), Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption : Physical and Biopharmaceutical Aspects, Pharm. Res. 12: 1561-1572.
Panayiotis P. Constantinides (2000), Self-Emulsifying Drug Delivery Formulations in the 21st Century: Challenges and Opportunities, in Controlled Drug Delivery : Designing Technologies for the Future (K. Park and R.J. Mrsny, Eds), ACS Symposium Series 752 : 284 - 296.
Panayiotis P. Constantinides and Kishor M. Wasan (2004), Advances in Lipid-Based Drug Solubilization and Targeting, in Advances in Lipid-Based Drug Solubilization and Targeting (Constantinides, P.P. and Wasan, K. M. Eds), Adv. Drug Del. Rev. 56 : 1239-1240.
Panayiotis P. Constantinides, Alex Tustian and Dean Kessler (2004), Tocol Emulsions for Drug Solubilization and Parenteral Delivery, in Advances in Lipid-Based Drug Solubilization and Targeting (Constantinides, P.P. and Wasan, K. M. Eds), Adv. Drug Del. Rev. 56 : 1243-1255.
Panayiotis P. Constantinides, Jihong Han and Stanley S. Davis(2006), Advances in the Use of Tocols as Drug Delivery Vehicles, Pharm. Res. 23 : 243-255.
Panayiotis P. Constantinides and Kishor M. Wasan (2007) Lipid Formulation Strategies for Enhancing Intestinal Transport and Absorption of P-glycoprotein (P-gp) Substrate Drugs : In vitro/In vivo Case Studies. J. Pharm. Sci. 96: 235-248.
Panayiotis P. Constantinides, Mahesh Chaubal and Robert Shorr (2008), Advances in Lipid Nanodispersions for Parenteral Drug Delivery and Targeting, theme issue on Lipid-Based Systems for Enhanced Delivery of Poorly Soluble Drugs (Christopher J.H. Porter, Kishor M. Wasan and Panayiotis P. Constantinides, Eds) Adv. Drug Del. Rev. 60 : 757-767.
Navdeep Kaur, Ashwini Gadre, Panayiotis P. Constantinides and Yashwant Pathak (2010), Nanomedicine : Trends and Perspectives on Technologies and Products, in Advances in Nanotechnology and Applications, Vol. 2, Center for Nanotechnology Education, Research and Applications, Sullivan University, College of Pharmacy, Louisville, KY.
Roy Haskell, Panayiotis P. Constantinides and Duxin Sun (2012), Perspectives in Pharmaceutical Nanotechnology, cover article January 2012 AAPS Newsmagazine.
George Mattheolabakis, Basil Rigas and Panayiotis P. Constantinides (2012) Nanodelivery Strategies in Cancer Chemotherapy : Biological Rationale and Pharmaceutical Perspectives, Nanomedicine 7(10) : 1577-1590.
Liu Changxiao, Panayiotis P. Constantinides, and Yazhuo, Li (2014) R&D in Drug Innovation : Reflections from the 2013 Bioeconomy Conference in China, Lessons Learned and Future Perspectives, Acta Pharmaceutica Sinica B 4(2) : 112-119.
Interview Publications, Commentaries and Professional Development Articles
Oral Drug Delivery Technologies : Tracking Clinical and Commercial Challenges, interviewed by Deborah Erikson, Fierce Pharma, March 2012.
Nanoparticles : A Look Forward, Amy Ritter (Moderator), BioPharm International 25 (6) :28 (2012)
Nanoformulations, Q&A session with Biopharmaceutical & Drug Delivery Consulting, LLC, moderated by Amy Ritter, Pharm Tech. July 2012.
Panayiotis P. Constantinides, Subhashis Chakraborty and Dali Shukla, Considerations and Recommendations on Traditional and Non-Traditional Uses of Excipients in Oral Drug Products, AAPS Open 2 (1) 1-6, 2016.
Join the Dialogue : Do We Need an Excipient Classification System Based on Their Traditional and Non-Traditional Uses in DrugProducts? AAPS Blog article posted on July 14, 2016.
Building a Consulting Business : A Practitioner's Perspective, AAPS News Magazine, May 2016 pp.31-34.
Recent Invited Talks (2013-2019)
Nanoparticle Technologies in Drug Formulation and Delivery : Design and Development Considerations and Case Studies, invited keynote talk at Evonik's Global Seminar Innovative Technologies in Healthcare, March 5-6, 2013, Mumbai, India.
Advances in Nano Drugs for Cancer Chemotherapy : Biopharmaceutical Trends and Perspectives and Case Studies, invited keynote talk at OMICS Group 3rd International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems (Pharmaceutica-2013), April 8-10, 2013, Northbrook, IL.
Project, Product or Company : A CSO/CTO Perspective, faculty at the 2013 Biotechnology Entrepreneurship Boot Camp, Session 3, Project, Product or Company : Assessment and Qualification of Technologies as a Basis for a Startup, BIO2013 International Convention, April 21-25, Chicago, IL.
Entrepreneurship and Starting a New Company, organizer and panelist in a roundtable on Biotech Career Transition : Adaptability to Change and Strategies for Success, AAPS National Biotechnology Conference, May 20-22, 2013, San Diego, CA.
The Scientific Basis for Fixed Dose Combination Products : Opportunities and Challenges, invited talk at the 2013 June LOL Conference on Fixed Dose Combination Drug Development : Clinical, Formulation and Regulatory Challenges, June 3-6, 2013, Madison, WI.
Integrated Drug Discovery and Development Strategy and Models, invited talk and Co-Chair, Session II R&D in Drug Innovation, Bio Eco 2013, June 25-26, 2013 Tianjin, China.
Drug Emulsions/Microemulsions/Nanoemulsions : Quality Characteristics and Performance Assessment, invited talk in the mini-symposium Overcoming Physical Stability Challenges with Multiphase Lipid Dispersed Systems and Impact on Product Quality and Performance, 2013 AAPS Annual Meeting, November 10-14, 2013, San Antonio. TX.
Enabling the Development and Life Cycle Management of Oral Poorly Soluble Drugs Using Lipid-Based Drug Delivery Systems, invited keynote talk at the 4th International Conference and Exhibition on Pharmaceutics and Novel Drug Delivery Systems, March 24-26, 2014 San Antonio, TX.
Parenteral and Oral Nanoemulsions and Nanosuspensions : Processing, Characterization and In Vitro/In Vivo Performance Assessment, invited talk and Chair, Solubility and Bioavailability Enhancement Workshop : Accelerating Translation of Challenging Compounds from Discovery to Clinical Testing and the Market, Ascendia Pharmaceuticals, LLC, April 28, 2014, North Brunswick, NJ.
Solubility and Bioavailability Enhancement in Drug Development : Drivers, Technologies to Consider and Assessment Strategies, invited keynote talk, Evonink’s 5th Solubility and Bioavailability Enhancement Symposium Utilizing Pharmaceutical Melt Extrusion and Spray Drying Techniques, May 13-14, 2014, South Plainfield, NJ.
Advances in Parenteral Drug Nanodispersions : Processing, Characterization and Case Studies, invited talk at the University of Nebraska Medical Center, Biopharma R&D Symposium, June 5-6, 2014, Omaha, NE.
Overview of Particle Engineering Needs in Pharma, co-organizer, speaker and panelist, Preconference Workshop on Particle Engineering Technology Selection and Partnership: A Roadmap to Commercialization, 2014 June LOL Conference, “Particle Engineering in API and Drug Product Design”, June 9-12, 2014, Madison, WI.
Advancing Oral Peptide Formulations to Clinic and Commercialization : Development Considerations, invited talk at the Workshop on Oral Peptide/Protein Delivery, July 12-13, 2014, CRS Annual Meeting, Chicago, IL.
Oral Emulsions, Microemulsions and Reverse Micelles for BCS II/IV and III Molecules, invited talk at the AAPS Workshop Improving Bioavailability by Lipid-Based Delivery Approaches, November 1-2, 2014, San Diego, CA.
Excipients as Inhibitors of the Absorption of Dietary Cholesterol : Principles and Case Studies with Nanostructured Aluminosilicates, invited talk at the symposium on Excipients as Atypical Actives in Nutraceuticals and Pharmaceuticals : Applications and Development Considerations, 2014 AAPS Annual Meeting, November 2-6, 2014, San Diego, CA.
Oral Lipid-Based Formulations as Enabling Strategy in Drug Discovery and Life Cycle Management, invited talk and member of the organizing committee, 1st International Congress of Controlled Release Society-Greek Local Chapter, May 27-28, 2015, Athens, Greece.
Non-Traditional Uses of Pharmaceutical Excipients : Applications and Development Considerations, invited talk, 1st International Workshop of MD Pharmacon Pharmaceutical Services Ltd on Advances in Scientific-Regulatory Issues in Drug Development and Authorization Processes, May 29, 2015, Athens, Greece.
Parenteral Drug Nanodispersions : Manufacturing, Characterization and In Vitro/In Vivo Performance Evaluation, keynote talk, OMICS Parenterals-2015 Conference, August 17-19, 2015, Chicago, IL.
Addressing Solubility and/or Permeability Challenges in Drug Development : Best Practices, invited talk and organizer, short course on Assessing and Applying Enabling Delivery Technologies and Formulation Tools to Oral Small Molecule (BCS II/IV) and Peptide Therapeutics (BCS III), 2015 AAPS Annual Meeting, October 25-29, 2015, Orlando, FL.
Starting a New Pharma/Biotech Company or Consulting Business : Why, What and How? talk in a professional development mini-session, 2015 AAPS Annual Meeting, October 25-29, 2015, Orlando, FL.
Effective Use of Lipids in Drug Delivery : Key Considerations and Best Practices, talk at the AAPS Workshop Enabling the Development of Oral Therapeutics with Innovation in Lipid Formulation Technologies, September 19-20, 2016, Plainsboro, NJ.
Dispersed Systems for Oral Peptides Incorporating Permeation Enhancers and Peptide Stabilizers, panelist in a dialogue and debate session Getting Oral Peptides to the Market : To Conjugate and/or Disperse the Peptide?, 2016 AAPS Annual Meeting, November 13-17, 2016, Denver, CO.
Oral Lipid Formulation Case Studies : Linking Drug Product Quality to Performance, talk at the 2017 June Land O' Lakes Pharmaceutical Conference, Material Sciences Approaches to Improving Drug Delivery Performance : From Discovery Through Manufacturing, June 5-8, 2017, Madison, WI.
Evaluation of Excipient Use in Drug Products : Traditional and Non-traditional Uses and Implications in Excipient Selection andFormulation Development, talk at the AAPS Short Course Pharmaceutical Excipients : Biopharmaceutical, Quality Control and Regulatory Considerations (served as co-organizer/co-chair), 2017 AAPS Annual Meeting, November 12-15, 2017, San Diego, CA.
Academia-Industry Partnerships : Success Considerations and Lessons Learned, talk in the symposium Academia-Biotech/Pharma Industry Partnerships : Opportunities and Challenges, 2017 AAPS Annual Meeting, November 12-15, 2017, San Diego, CA.
Development and Commercialization of Oral Peptides/Proteins : Trends and Perspectives, keynote talk at the 12th World Drug Delivery Summit, September 24-26, 2018, Chicago, IL.
Is an Oral Lipid-based Formulation Best for Your Molecule? Insights from Exclusive Survey on Strategies for Poorly Soluble Molecules, co-presented with Ronak Savla of this March 27, 2019 Catalent Webinar.