Welcome to Biopharmaceutical & Drug Delivery Consulting (BPDDC).

Founded in 2004 by Dr. Panayiotis P. Constantinides and incorporated in the State of Illinois as LLC, BPDDC provides  strategic, technical and business development consulting in drug delivery technology and drug product development of New Molecule Entities (NMEs) and reformulations of approved drugs. Dr. Constantinides is a biopharmaceutical and drug delivery scientist, entrepreneur, seasoned research and development executive and experienced consultant with strong academic credentials, broad experience and successful track record in academia, start-up and development stage biopharmaceutical companies and established multinational pharmaceutical organizations.

The specific areas of consulting services are summarized below:

Drug Discovery support with preclinical, toxicology and FIH formulations for oral drugs exhibiting drug dissolution and/or membrane transport or intestinal permeability limited absorption (BCS Class II, III and IV).

Clinical and commercial formulation development for oral and parenteral drugs immediate and controlled release.

Biomedical applications of nanomaterials and nanoparticles.

Excipient characterization and qualification and impact on product performance.

Design and development of versatile  lipid-based systems for oral, parenteral and topical  drug delivery, such as liposomes, emulsions, microemulsions and nanoemulsions, micelles and nanosuspensions, solid lipid nanoparticles, and SEDDS.

Design and development of lipidic and polymeric drug complexes and conjugates.

Processing and manufacturing aspects of formulations.

Pre-formulation, formulation and analytical development aspects of the CMC for IND/ANDA/NDA filings.

Working knowledge of parenteral solutions and lyophilized formulations, emulsions, oral liquid, semi-solid, solid dosage forms and topical formulations (creams, gels, lotions and ointments).

Strategic product/technology evaluations and commercial development assessment along with licensing recommendations.

Intellectual property evaluation and expert witness in patent litigations.

Identifying, structuring and managing milestone-driven feasibility studies, research and product development agreements with third parties.

Therapeutic areas include, Cancer, Infectious Diseases, Inflammation and Tissue Repair, Cardiovascular, Digestive Diseases and Metabolic Disorders.

Clients include, early stage, small and large biotech, pharma and specialty pharma companies, nutraceutical, chemical and nanotechnology companies, CROs/CMOs and academic institutions.